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Rom. J. Biophys. 2010 20(2): 93-100

ON THE GALANTAMINE INTERACTION WITH ARTIFICIAL LIPID MEMBRANES

A. IFTIME, ANCA POPESCU, CONSTANŢA GANEA

Department of Biophysics, “Carol Davila” University of Medicine and Pharmaceutics,
8 Eroii Sanitari Blvd, 050474, Bucharest, Romania

Abstract. Using an electrophysiological method, Black Lipid Membrane (BLM), we have studied the modifications induced by galantamine (GAL) on the electric properties of artificial lipid membranes formed either with diphytanoyl-phosphatidylcholine+octadecylamine (PCOA) or with 1,2-Dioleoyl-sn-Glycero-3-[phospho-rac-(1-glycerol)] (DOPG). The observed capacitance and conductance changes of artificial lipid bilayers depended both on the concentration of GAL and on the charge carried by the lipids. Our results suggest that more than one mechanism is responsible for the GAL interaction with the lipid membrane.
Key words: Galantamine, BLM, PCOA, DOPG

Author's e-mail: ad_if@yahoo.co.uk

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