Faculty of Physics, “Alexandru Ioan Cuza” University, 11 Carol I Blvd., Iași, Romania
DNA interaction with UV radiation is an actual problem for medicine and biology, as prolonged sun exposure is the cause for the majority of skin cancers. This paper is focused on the computational modeling of UV light interaction with cytosine nucleotide by applying quantum chemical approach based on semi-empirical method. The comparison of some energetic and structural parameters of cytosine nucleotide and its two derivatives resulted following UV radiation absorption has evidenced the linear dependence of dipole moment and total energy as provided by optimized structure analysis.
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