M.A. IBRAHIM#, M.H. IBRAHIM, H.A. AYOUB
Physics Department, Faculty of Science, Suez Canal University, Ismailia, Egypt
#Present address: King Abdulaziz University, Faculty of Science, Physics Department, Arar, KSA
Abstract. Diabetes Mellitus is one of the most costly burdensome chronic diseases of our time and is condition that is increasing in epidemic population in the whole world. Diabetes mellitus is regarded as a syndrome, a collection of disorders that have hyperglycemia as the hallmark. Non-insulin dependent diabetes mellitus is now epidemic in many countries undergoing modernization and industrialization. High levels of glucose, which is the main indicator of diabetes mellitus, were attributed to oxidative processes. Therefore, this work interests in measuring the glutathione and lipid peroxidation levels. The present work also investigates the influence of some antioxidants on the glucose concentration. More than 30 persons who had a negative history of any diabetes mellitus were used as controls and more than 80 patients with different stages of diabetes mellitus were examined. Seven groups of Sprague Dawely rats (8 rats per group) were also used. The results showed that hydrogen peroxide (H2O2) is produced during the progress of the disease and increases with a percentage of about 27%. On the other hand, glutathione (GSH) content reduced with a percentage of about 20%. 200 mg/kg of body weight of vitamin E, vitamin A, vitamin C, ginseng extract and 50 μmole of nicotinamide adenine dinucleotide (NADH) showed good effects on both enhancement of glutathione content (up to 76.9%) in blood and decreasing lipid peroxides (to 19.4%) after 24 hours of administrating the rats with H2O2. Results also showed that diabetes is accompanied by an increase in electrical conductivity and a decrease in intrinsic viscosity.
Key words: diabetes, oxidative stress, antioxidants, conductivity.