EVA KATONA*, GYONGYVER KATONA**, A. CAPLANUSI**, MAGDA TUFEANU*, CEZARINA NEGREANU*, DIANA IONESCU*

*Department of Biophysics, „Carol Davila” University of Medicine and Pharmaceutics, Bucharest, Romania
**Department of Medical Biochemistry, „Carol Davila” University of Medicine and Pharmaceutics, Bucharest, Romania

Abstract. Steady-state fluorescence polarization measurements showed that N,N-dimethylaminoethyl hydrochloride esters of phthaloyl-glycine (Pht-Gly) and phthaloyl-leucine (Pht-Leu) induce increase in the lipid order parameter and membrane rigidization, while quaternary ammonium salts of Pht-Gly and Pht-Leu cause diminution of lipid packing density in the polar head-group region and produce fluidization of the human leukemic T cells plasma membrane inner surface. Progressive metabolic impairment of cells leads to changes in plasma membrane properties, modulation, and finally loss of membrane effects of these antibacterial agents.

Author’s e-mail: eva_katona@yahoo.com

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