DANIELA BÎNDAR*, LILIANA TARŢĂU**, ANA GÂRLEA*, LOREDANA NIŢĂ***, V. MELNIG*
*Faculty of Physics, COMB Laboratory, “Al.I. Cuza” University, 11A, Carol I Blvd., Iaşi, Romania
**Faculty of Medicine, “Gr.T. Popa” University of Medicine and Pharmacy, 16, Universității St., Iaşi, Romania
***LAMINAST Laboratory, “Petru Poni” Institute of Macromolecular Chemistry, 41A, Grigore Ghica Vodă St., Iaşi, Romania
Abstract. This paper is focused on the experimental researches of the preparation and effects of magnesium chloride soft matter vesicles carrier, in a behavioral model in mice. This model evaluates exploratory activity and motor coordination in mice. The soft matter vesicles were made by magnesium chloride immobilization inside lipid vesicles and their stabilization with chitosan. Their dimensions are ranging between 78 and 300 nm and present a moderate stability. Magnesium chloride 1 mmol/kg body weight entrapped in soft vesicles was orally administrated to one group of 7 mice, another two groups being treated with distilled water (the control group) and with magnesium chloride 1 mmol/kg body weight. It was observed that the magnesium chloride vesicles determined a prolonged decrease of both horizontal and vertical mice movements compared with the same dose of non entrapped magnesium chloride, more than 12 hours after substance administration. Our results show that in the mouse model of behavioral manifestations used, magnesium soft matter vesicles carrier decreased both global motor behavior and the number of escape attempts, which could correspond somehow to sedation in humans.
Key words: magnesium chloride, soft vesicles, behavioral model.