EBTESAM A. MOHAMAD
Biophysics Department, Faculty of Science, Cairo University, 12613, Giza, Egypt, mobile number: +201015082266
Ginger extract and capsaicin are used as phytochemical drugs. These components can affect the growth of prostate cancer and decrease its rate of development without affecting the normal cells comparing to current chemotherapy drugs. And whereas the more suitable molecular structure, will result in more drugs that are potent. The aim of this study is to predict the binding of capsaicin, 6-gingerol, and 6-shogaol to the over expressed androgen receptor (NR3C4) using an in silico model. The docking analysis was performed using SCIGRESS 3.0 software. The results showed that the capsaicin and 6-gingerol have close values of binding energy, while 6-shogaol takes relatively higher value, 6-shogaol having the strongest binding energy (≈ –181 kcal/mol) to the active sites of NR3C4. The 6-shogaol has the capacity to establish 8 hydrogen bonds with NR3C4 receptor. Therefore, 6-shogaol have a potential to be developed as an efficient treatment for prostate cancer.
Key words: Ginger, prostate cancer, androgen receptor, 6-shogaol.
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