INTERNAL DOSIMETRY FOR RADIONUCLIDE DIAGNOSTIC IN NUCLEAR MEDICINE BONE SCAN PROCEDURES

M. ATI*#, S.H. OTHMANE**, M. BOUZID**

*Faculty of Medicine, “Abdelhamid Ibn Badis” University of Mostaganem, 27000 Mostaganem, Algeria
**CAC Adrar, BP 143 Sidi Mohamed Belkebir, Adrar, 01000, Algeria

This study aims to estimate the absorbed doses and biological parameters in the critical organs of patients during bone scan scintigraphy, using SPECT data based on technetium 99m-methyl diphosphonate (99mTc-MDP) in nuclear medicine (NM) procedures. Tc uptake of different critical organs (ROIs) such as kidneys and bladder were calculated at different times (0.2 h,  1 h, 1.45 h, and 3 h) after the administration of mean activity A0 equal to 11.53 mCi. The absorbed dose, biological half- life (T1/2), and resident time (τ) were computed using Medical Internal Radiation Dosimetry (MIRD) Report 13 of biokinetic model. The data were analyzed using a computational toolkit called (IntDosCalc) developed under Matlab code. The results of the present study showed that the value of the absorbed dose for critical organs such as the kidney and bladder were 0.007 and 0.393 mGy per unit of administrated activity, respectively. The cumulated activity, residence time, effective half-life and biological half-life were discussed in detail.

Key words: Absorbed dose, nuclear medicine, medical internal radiation dose, technetium-99m

Corresponding author’s e-mail: moncef.ati@univ-mosta.dz

 

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