MARIA-MINODORA IORDACHE, MIHAELA-GEORGETA MOISESCU#, EUGENIA KOVÁCS, T. SAVOPOL
Biophysics and Cell Biotechnology Dept., ”Carol Davila” University of Medicine and Pharmacy, P.O.Box 3543, Bucharest, Romania
Abstract. Liposomes are largely used today as drug carriers. Their behavior in various chemical and physical environments should be well known in view of a rational design of vesicles of appropriate formulations. We investigated the liposomal membrane behavior under different physical and chemical conditions such as exposure to antibiotics, radiofrequecy fields and thermal changes. Measuring the Generalized Polarization of laurdan-labeled liposomes in the presence of the charged aminoglycoside gentamicin, under exposure to 2.45 GHz and under cyclic variation of temperature, the phase transition behavior of the phospholipids was characterized.
Key words: liposomes, gentamicin, microwaves, fluorescence, generalized polarization, phase transition.
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