EMANUELA CICARMA*, T.P. CORHAN*, ANA MARIA VLĂDĂREANU**, H. BUMBEA**, EUGENIA KOVÁCS*, MIHAELA G. MOISESCU*#, T. SAVOPOL*
*Department of Biophysics & Cell Biotechnology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
**Department of Hematology, Emergency University Hospital, Bucharest, Romania
A large variety of platelets dysfunctions have been described in myeloid neoplasm. In this study we evaluate the alterations in membrane fluidity of blood platelets in patients with various entities of myeloid malignancies. Membrane fluidity was assessed by fluorescence anisotropy measurements. Platelet membrane from acute myeloid leukemia (AML) and myelodysplastic syndrome patients was found to be significantly more rigid compared with controls/normal, but it became more fluid if the disease progressed towards a more severe status. We consider that detection of these modifications may be useful for a better insight in cell abnormalities occurring in this pathology.
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