V. BĂDESCU*, LAURA ELENA UDREA*, O. ROTARIU*, RODICA BĂDESCU**, GABRIELA APREOTESEI**
*National Inst. of Research and Development for Technical Physics, 47 Mangeron Blvd., Iaşi, Romania,
**Department of Physics, “Gh. Asachi” Technical University, 67 Mangeron Blvd., Iaşi, Romania
Abstract. Our work presents some results of numerical simulations and in vitro testing of a magnetic filtration system designed for removing toxin-bounded magnetic microspheres previously administrated intravenously in the bloodstream of human body. The filter consists of an array of biocompatible capillary tubing and magnetizable wires adjacent in the exterior of these (axial HGMS cells). The wires are magnetized perpendicular to their axes by a spatially uniform magnetic field. First, the capture efficiency of a single filtration cell was analyzed using a mathematical model. Second, the one-pass effectiveness to remove magnetic chitosan microspheres from solutions simulating human blood was experimentally verified. Based on mathematical modelling which relates the separation cell geometrical and operational parameters, we present a criterion for the optimization of the recovery, for which the theoretical filtration efficiency is 100%. The theoretical and experimental data correlated well at low flow velocities (< 4.5 cm/s) and high magnetic fields (>48 kA/m). Our model filter unit removed > 90% in a single pass of the magnetic microspheres (1 – 3 μm diameter and 450 kA/m saturation magnetization) from water at mean flow velocity ≤ 8.0 cm/s and from blood mimic fluids (ethylene glycol–water solutions) at mean flow velocity ≤ 2.0 cm/s.
Key words: magnetic particles, filter, extracorporeal, blood purification.
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