A. IFTIME, ANCA POPESCU, CONSTANŢA GANEA
Department of Biophysics, “Carol Davila” University of Medicine and Pharmaceutics, 8 Eroii Sanitari Blvd, 050474, Bucharest, Romania
Abstract. Using an electrophysiological method, Black Lipid Membrane (BLM), we have studied the modifications induced by galantamine (GAL) on the electric properties of artificial lipid membranes formed either with diphytanoyl-phosphatidylcholine+octadecylamine (PCOA) or with 1,2-Dioleoyl-sn-Glycero-3-[phospho-rac-(1-glycerol)] (DOPG). The observed capacitance and conductance changes of artificial lipid bilayers depended both on the concentration of GAL and on the charge carried by the lipids. Our results suggest that more than one mechanism is responsible for the GAL interaction with the lipid membrane.
Key words: Galantamine, BLM, PCOA, DOPG
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