ELENA DANIELA CĂŞĂRIU*, **, BOGDANA VÎRGOLICI**, DANIELA LIXANDRU**, MIHAELA STANCU***, MARIA GREABU**, ALEXANDRA TOTAN**, DANIELA MIRICESCU **, MARIA MOHORA**
* S.C. CABINET DANAMED S.R.L.
**Department of Biochemistry, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,
*** National Sanitary Veterinary and Food Safety Agency
Abstract. Dyslipidemia in childhood predicts the development of atherosclerosis in young adults. The aim of this study is to investigate the relation of apoB/apoA-I ratio with different cardiovascular risk factors, in obese children. A total of 41 overweight obese children and 30 healthy children were enrolled. Correlations between apoB/apoA-I ratio with different cardiovascular risk factors: C reactive protein (CRP), blood pressure, dyslipidemia markers, gamma-glutamyl transferase activity were calculated. Ultrasounds were used for carotid intima-media thickness (IMT) and fatty liver estimation. All the studied parameters were higher in obese children versus normal subjects. ApoB/apoA-I ratio was correlated (p < 0.05) with γ-GT activity (r = 0.35), IMT (r = 0.38), CRP (r = 0.59), alanine aminotransferase activity (r = 0.37), waist circumference (r = 0.44) and diastolic blood pressure (r = 0.33), while apoA-I was inversely related to triglycerides (r = –0.44), CRP (r = –0.39) and waist circumference (r = –0.42). HDL-C was positively correlated with apoA-I (r = 0.82) and negatively with apoB/apoA-I (r = –0.65), while LDL-C was positively correlated with apoB (r = 0.79). The apoB/apo A-I ratio is higher in obese children than in normal children. The ratio is correlated with increased values of other cardiovascular risk factors and fatty liver markers.
Key words: obesity, children, apoB/apoA-I ratio, atherosclerosis, intima-media thickness, cardiovascular risk factors.
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