A STUDY ON PORE FORMATION DYNAMICS IN BIO-MIMICKING MEMBRANE SYSTEM

A. GHOSH*, S. MANNA**, S. DAS*, R. BASU***, P. NANDY*

*Physics Department, Jadavpur University, Kolkata-700032, India
**”Jagadis Bose” National Science Talent Search, 1300, Rajdanga Main road, Kasba, Kolkata-700107, India
***Department of Physics, “Jogamaya Devi” College, Kolkata-700026, India

Abstract. Transmembrane electrical activities are modulated due to the presence of membrane embedded pores and channels. We have studied the role of lipid membrane which mimics the biological membrane and plays an important role in charge conduction mechanism through membrane. Electrical currents, arising from conduction of ions or charges through field induced pores, fluctuate due to its own dynamics. We have performed statistical analysis on this current fluctuation data under different voltage clamp conditions. The result shows that after a certain cut off value the probability distribution of current fluctuation values follow a power law up to a certain range. Additionally the power law of magnitude of large fluctuations indicates the scale-invariance of size of pores and power law of first time return probability indicates that the dynamical behaviour during transport through pores is correlated and the underlying dynamics during the conduction through pores is analogous to the ion channel dynamics
Key words: mimetic membrane, lipidic pore, power law, membrane dynamics, electroporation.

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