SMARANDA STOLERU*, H. PĂUNESCU*#, A. ZUGRAVU*, SORINA VASILE**, OANA ANDREIA COMAN*, I. FULGA*
* Department of Pharmacology and Pharmacotherapy, “Carol Davila” University of Medicine and Pharmacy, 8, Eroii Sanitari, Bucharest, Romania
** Emergency Universitary Hospital, Bucharest, 169, Splaiul Independenței, Bucharest, Romania
Pain is one of the main parameter used for evaluating the clinical efficacy of anticancer drugs. Previous research suggest that some oncologic drugs have an analgesic effect in acute administration, independent from the analgesic effect resulted from the tumor shrinkage. In this paper we analyzed the analgesic effect of oxaliplatin. We conducted two experimental tests: writhing test and hot plate test, using male swiss albino mice. The tested substance, oxaliplatin, was intraperitoneally administered, 1 hour before tests, in doses of 2 mg/kg body weight – bw (lethal dose 50/10) and 4 mg/kg bw (lethal dose 50/5), respectively. In writhing test, the number of abdominal contractions, when compared with the control group, increased for the high dose in a statistically significant manner. For the low dose of oxaliplatin, the number of writhes slightly decreased. In the hot plate test, none of the doses of oxaliplatin have produced statistically significant effects in the paw licking and jumping latency parameters. Further research on analgesic effects of platinum derivatives will clarify issues regarding the statistical significance.
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