THE EFFECT OF THE GLIAL CONDITIONED MEDIUM ON BRAIN AND SPINAL CORD MICROGLIAL CELLS IN CULTURE

A.-F. DEFTU#, ANTONIA-TEONA DEFTU, VIOLETA RISTOIU

Department of Anatomy, Animal Physiology and Biophysics, University of Bucharest, Romania

Glial cells, in particular microglia, are important regulators of neuronal functions. Microglia are a heterogeneous population that react differently depending on the activating agents and on their location in the nervous system. Little is known about the action of the glial conditioned medium (GCM) on the membrane currents of these cells. Our study indicates that the GCM from a mixed glial culture has no effect on the resting membrane potential and is inducing a decreasing trend of the current density.

Corresponding author’s e-mail: bio.florian@yahoo.com

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