SEHAM M. EL-MARAKBY*, NABILA S. SELIM*#, O.S. DESOUKY*, HODA A. ASHRY*, A.M. SALLAM**
*Biophysics Laboratory, Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), AEA, POB 29 Madinat Nasr Cairo, Egypt
**Physics Department, Faculty of Science, Ain Shams University, Cairo, Egypt
The aim of the present work is to study the prophylactic and mitigation effect of poly-MVA against acute whole body gamma irradiation. Adult male rats were exposed to 6 Gy single dose from Cs-137 source. The electrical properties of erythrocytes suspension were measured in the frequency range 40 kHz to 5 MHz. The lipid peroxidation of liver homogenate, the mean corpuscular volume, hemoglobin concentration and hematocrit were also measured. The animals received daily oral administration of 2 mL/kg body weight of poly-MVA for three different time intervals. The study of the prophylactic effect was applied by two modes of administration: two weeks before irradiation and another group which received continuous administration for two weeks before and two other weeks after irradiation (total time of administration 28 days). The mitigation effect was examined by administration of poly-MVA for two weeks after irradiation. The results showed that exposure to gamma radiation caused a decrease in the AC conductivity, relative permittivity, area under the loss curve and membrane effective capacitance, while caused increase in the lipid peroxidation I day after exposure to radiation. The later change persisted until the 14th day recorded after irradiation. The administration of poly-MVA after irradiation alleviated the radiation-induced damage as appeared from the non-significant change in the measured parameters compared to control. The group which received continuous administration, before and after irradiation, showed better results compared to the group which received administration before irradiation only. The obtained results showed that poly-MVA can be used as prophylactic as well as mitigator agent on planned and accidental radiation exposure.
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